Conveners
Radionuclides Production & Application: PAR 1
- Andreas Tรผrler
- Antonia Denkova (TU Delft)
Radionuclides Production & Application: Poster session
- There are no conveners in this block
Radionuclides Production & Application: PAR 2
- Dominic Maertens (PanTera NV)
- Jiลรญ Mizera (Nuclear Physics Institute, Academy of Sciences of the Czech Republic)
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Dominic Maertens (PanTera NV)5/12/26, 10:30โฏAMProduction and Application of RadionuclidesInvited
Aim:
A promising nuclide in radioligand therapy (RLT) is Actinium-225 (Ac-225), a rare alpha-emitting radionuclide that has garnered attention for its potent cytotoxicity and precision in targeting malignant cells. A growing body of preclinical and clinical evidence support its effectiveness and further increases the demand for Ac-225. However, despite its therapeutic promise, the clinical...
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Haohan ZHANG (Paul Scherrer Institut (PSI))5/12/26, 11:00โฏAMProduction and Application of RadionuclidesVerbal
Noble gases are members of group 18 in the periodic table and known for their chemical inertness. Radioisotopes of noble gases have found multiple applications, including atmospheric tracing, and medical imaging. In the development of Generation IV nuclear reactor technologies, particularly lead-cooled fast reactors (LFRs), radioisotopes of Kr and Xe are proposed as indicators for the...
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Dr Naohiko Otuka (International Atomic Energy Agency)5/12/26, 11:20โฏAMProduction and Application of RadionuclidesVerbal
Radioisotope production cross sections and other nuclear reaction data measured in the world have been compiled by the Nuclear Reaction Data Centres (NRDC) for the EXFOR library under coordination by the IAEA Nuclear Data Section (IAEA NDS). IAEA's recommendation of charge-particle induced cross sections for medical isotope production fully relies on the experimental knowledge stored in the...
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Marouscha Puister5/12/26, 11:40โฏAMProduction and Application of RadionuclidesVerbal
Aim
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Holmium-166 ($^{166}$Ho) is a promising radionuclide for targeted radionuclide therapy. The combination of its high energy beta radiation for treatment and low energy gamma radiation for imaging makes it suitable for theragnostic purposes. Unfortunately, this radionuclide is not widely used yet because it remains difficult to obtain $^{166}$Ho in high enough specific activity to... -
taylan รZBEY (Turkish Energy, Nuclear and Mineral Research Agency)5/12/26, 5:15โฏPMProduction and Application of RadionuclidesPoster
Our 30 MeV cyclotron facility routinely produces 123I-NaI from enriched 124Xe gas and 201Tl-TlCl from enriched 203Tl for clinical nuclear medicine applications. 123I-NaI is used for thyroid scintigraphy and 201Tl-TlCl for myocardial perfusion imaging. Routine radiopharmaceutical production processes demonstrate that our infrastructure for target preparation, irradiation, radiochemistry, and...
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Gazi Gรผneล (TURKISH ENERGY, NUCLEAR AND MINERAL RESEARCH AGENCY (TENMAK))5/12/26, 5:18โฏPMProduction and Application of RadionuclidesPoster
Cobalt-57 is an essential calibration radionuclide for medical imaging systems and quality control phantoms. This work reports Co-57 production, with emphasis on enriched nickel target preparation and radiochemical separation.
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The process design was guided by Monte Carlo simulations using the PHITS code, which showed that by using enriched Ni-58 significantly reduces irradiation time by... -
Elisabete De Nadai Fernandes (Nuclear Energy Center for Agriculture, University of Sรฃo Paulo)5/12/26, 5:21โฏPMProduction and Application of RadionuclidesPoster
Using 65ZnO radiolabeled by neutron activation analysis (NAA), this study aimed to investigate the blood mineral profile in ewes supplemented with micro and nanoscale zinc oxide. Eight Santa Ines ewe, with 10 months old and weighing 23.6 ยฑ 2.0 kg, were used and randomly assigned to two equal treatment groups. One group received capsules containing 50 mg of 65ZnO nanoparticles (40 nm), and the...
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Feng Yin (Institute for Radiation Sciences, The University of Osaka)5/12/26, 5:24โฏPMProduction and Application of RadionuclidesPoster
Astatine-211 ($^{211}\mathrm{At}$) is a valuable ฮฑ-emitter for targeted alpha therapy (TAT) due to its unique decay properties. It releases only a single ฮฑ-particle per decay, which facilitates accurate dosimetry and produces low-energy X-rays suitable for in-vivo imaging and tracking [1]. $^{211}\mathrm{At}$ can be produced by irradiation of bismuth, a relatively abundant and low-cost...
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Naohiko Otuka (International Atomic Energy Agency)5/12/26, 5:27โฏPMProduction and Application of RadionuclidesPoster
Charged-particle activation is a techinique to measure charged-particle induced nuclear reaction cross sections leaving radionuclides by measuring the activities of the radioactive products. When production of the radionuclides is induced not only by primary charged-particle beam particles but also by secondary particles, the contribution of the secondary particles must be taken into account....
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Dr Anna Cwanek (Institute of Nuclear Physics, Polish Academy of Sciences)5/12/26, 5:30โฏPMProduction and Application of RadionuclidesPoster
Radiochemical analysis of $^{237}\mathrm{Np}$ ($T_{1/2}$=2.14 Ma) is important in a number of fields, including nuclear forensics, environmental analysis, and measurements throughout the nuclear fuel cycle. However, the analysis is challenging due to the limited availability of suitable Np tracers. $^{235}\mathrm{Np}$ ($T_{1/2}$=396.1 d) was identified as a promising tracer for yield...
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Masashi Murakami (Institute for Radiation Sciences, The University of Osaka)5/12/26, 5:33โฏPMProduction and Application of RadionuclidesPoster
Astatine-211 ($^{211}$At) is a promising radionuclide for targeted alpha therapy. However, its short half-life (7.2 h) necessitates a decentralized production network. In Japan, multiple cyclotron facilities enable such distribution. Nevertheless, differences in target characteristics, irradiation parameters, and purification procedures may alter the chemical species of $^{211}$At, potentially...
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Kai Taneichi (Japan Nuclear Fuel Chemical Analysis Co., Ltd.)5/12/26, 5:36โฏPMProduction and Application of RadionuclidesPoster
Our previous research showed that Sr(II) can be separated from simulated high level-liquid waste (HLLW) using extraction chromatography with distilled water as elution solution. In order to utilize the large amounts of 90Sr separated from HLLW, it is expected that 90Y, a daughter nuclide of 90Sr, will be separated from 90Sr-90Y group and used as a radioactive material in the medical field. For...
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Atsushi Toyoshima (Institute for Radiation Sciences, the University of Osaka)5/12/26, 5:39โฏPMProduction and Application of RadionuclidesPoster
Neutron Activation involves the emission of prompt gamma rays, which impart recoil energy to the activated nucleus and can induce structural perturbations in molecular systems. This gamma-recoil process is generally expected to cause bond cleavage or ligand dissociation, thereby compromising molecular integrity. However, the extent to which molecular structures can survive such processes has...
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Naoki Osawa (Nagaoka University of Technology)5/12/26, 5:42โฏPMProduction and Application of RadionuclidesPoster
The alpha-emitting radionuclide 225Ac has attracted considerable interest for targeted alpha therapy, a promising cancer treatment modality. Following the demonstration of its efficacy in the treatment of metastatic cancer, demand for it has surged and is expected to continue to rise. The current method for producing 225Ac relies on separating decay products from a 229Th generator; however,...
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Gauri (Delft University of Technology)5/14/26, 3:30โฏPMProduction and Application of RadionuclidesVerbal
Technetium-99m (99mTc) remains the most widely used gamma emitting radionuclide for diagnostic nuclear medicine. At present, its production relies predominantly on the fission of uranium-235 (235U) to generate the parent isotope molybdenum-99 (99Mo), a process that produces substantial quantities of long-lived nuclear waste and raises concerns regarding...
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Prof. Andreas Tรผrler (University of Bern)5/14/26, 3:48โฏPMProduction and Application of RadionuclidesVerbal
Photonuclear reactions have been known since nearly 100 years, but only recently, discussions about using this type of reaction for the production of radionuclides for medical applications (i.e. diagnosis and therapy) have surfaced. In a photonuclear reaction a high-energy gamma-ray is interacting with a target nucleus, whereby a particle (or several particles) such as protons or neutrons are...
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Xiuyun Chai5/14/26, 4:06โฏPMProduction and Application of RadionuclidesVerbal
Pm-149 is a promising ฮฒโป-emitting radiolanthanide with moderate beta decay energy (Eโโโ = 1.07 MeV) and a half-life of 53.1 hours. Besides these therapeutic characteristics, ยนโดโนPm also emits a low-abundance imageable gamma ray at 286 keV with an intensity of around 3%. However, its broader clinical translation is currently limited by challenges in reliable production and efficient...
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Tomasz Mrรณz (Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences)5/14/26, 4:24โฏPMProduction and Application of RadionuclidesVerbal
Intermediate-energy cyclotrons providing 25โ60 MeV proton beams represent essential infrastructure for generating the experimental nuclear-reaction cross sections required for credible cyclotron-based applications. This energy interval uniquely encompasses the regime in which reaction yields, radionuclidic purity, and impurity formation are governed by rapidly varying excitation functions...
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Andrea Tzeitel Loria Basto (Johannes Gutenberg Universitรคt Mainz)5/14/26, 4:42โฏPMProduction and Application of RadionuclidesVerbal
The study of chemical and physical properties of actinides is of essential interest in the field of nuclear science. Our group at Mainz University specializes in the production and characterization of tailor-made actinide samples for both national and international collaborations. Einsteinium (element 99) and fermium (element 100) have been in our focus most recently. A sample of Es-254,...
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