May 15 – 20, 2022
Casino Conference Centre
Europe/Prague timezone

Accumulation and Effect of Silver Nanoparticles Functionalized with Spirulina platensis on Rats

Not scheduled
Casino Conference Centre

Casino Conference Centre

Reitenbergerova 4/95, Mariánské Lázně, Czech Republic
Poster Nuclear Analytical Methods Nuclear Analytical Methods


Inga Zinicovscaia (Joint Institute for Nuclear Research)


The effect of unmodified and functionalized Spirulina platensis biomass silver nanoparticles on rats during prolonged oral administration was assessed. Silver nanoparticles were characterized by using transmission electron microscopy, while their uptake by the biomass was confirmed using scanning electron microscopy and energy dispersive analysis. The content of silver in the different organs of rats after a period of administration (28 days) or after an additional clearance period (28 days) was ascertained by using neutron activation analysis. In animals administrated with the unmodified nanoparticles, the highest content of silver was determined in the brain and kidneys, while in animals administrated with AgNP-Spirulina, silver was mainly accumulated in the brain and testicles. After the clearance period, silver was excreted rapidly from the spleen and kidneys; however, the excretion from the brain was very low, regardless of the type of nanoparticles. Hematological and biochemical tests were performed in order to reveal the effect of nanoparticles on rats. The difference in the content of eosinophils in the experimental and control groups was statistically significant. The hematological indices of the rats did not change significantly under the action of the silver nanoparticles except for the content of reticulocytes and eosinophils, which increased significantly. Changes in the biochemical parameters did not exceed the limits of normal values. Silver nanoparticles with the sizes of 8–20 nm can penetrate the blood–brain barrier, and their persistence after a period of clearance indicated the irreversibility of this process

Primary authors

Inga Zinicovscaia (Joint Institute for Nuclear Research) Dr Liliana Cepoi (Institute of Microbiology and Biotechnology) Dr Ludmila Rudi (Institute of Microbiology and Biotechnology) Dr Tatiana Chiriac (Institute of Microbiology and Biotechnology) Ms Alexandra Peshkova (Joint Institute for Nuclear Research) Dr Dmitrii Grozdov (Joint Institute for Nuclear Research) Ms Anastasia Cepoi (Institute of Microbiology and Biotechnology)

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