May 15 – 20, 2022
Casino Conference Centre
Europe/Prague timezone

Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents (RADEKOR) – a joint project

May 17, 2022, 5:21 PM
6m
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Poster Radionuclides in the Environment, Radioecology Environmental Radioactivity

Speaker

Dr Astrid Barkleit (Helmholtz-Zentrum Dresden-Rossendorf, Institute of Resource Ecology)

Description

In case radionuclides (RN) enter the food chain and are incorporated by humans, they pose a possible health risk due to their radio- and chemotoxicity. To precisely assess the health risk after oral incorporation of RN with food and beverages and to apply effective decontamination methods, it is mandatory to understand the processes of RN biokinetics on both cellular and molecular scale. Within the joint research project “Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents (RADEKOR)”, quantitative excretion analysis and biokinetic modeling of orally incorporated RN are performed. Additionally, these macroscopic investigations are combined with molecular speciation studies of RN in artificial fluids of the alimentary tract of humans and cytotoxicity studies with respective human and rat cell lines both in the absence and presence of decorporation agents. Aim of the project is to expand the knowledge of processes underlying RN interactions within the human alimentary tract on a cellular and molecular scale to establish a precise biokinetic model as well as to contribute to the development and improvement of nuclide specific decontamination methods.
This joint project is funded by the German Federal Ministry of Education and Research (grant number 02NUK057). The funding period is from July 2020 to December 2023 and cooperation partners are: Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Technische Universität Dresden (TUD), Leibniz-Universität Hannover (LUH), VKTA - Radiation Protection, Analytics & Disposal (VKTA), and Karlsruhe Institute of Technology (KIT).

Primary author

Dr Astrid Barkleit (Helmholtz-Zentrum Dresden-Rossendorf, Institute of Resource Ecology)

Co-authors

Dr Anne Heller (Technische Universität Dresden, Analytical Chemistry, Radiochemistry/Radioecology) Prof. Clemens Walther (Leibniz Universität Hannover, Institute of Radioecology and Radiation Protection) Dr Diana Walther (VKTA – Radiation Protection, Analytics & Disposal Rossendorf) Mr Wolfgang Raskob (Karlsruhe Institute of Technology, Institute for Thermal Energy Technology and Safety)

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