RadChem 2022

Session

Radionuclides Production & Application

17 May 2022, 10:30

Casino Conference Centre

Conveners

Radionuclides Production & Application: PAR 1

• Antonia Denkova (TU Delft)
• Xiaolin Hou (Technical University of Denmark, Center for Nuclear Technologies)

Radionuclides Production & Application: PAR 2

• Pavol Rajec (BIONT a.s. Bratislava)
• Jiří Mizera (Nuclear Physics Institute, Academy of Sciences of the Czech Republic)

Radionuclides Production & Application: PAR Poster

• There are no conveners in this block

967. Updating the nuclear databases: re-measurement of the half-life of Sm-146, Gd-148, and Dy-154

Nadine Mariel Chiera (Paul Scherrer Institute)

17/05/2022, 10:30

Production and Application of Radionuclides

Verbal

During the last years, an increased effort was put into the measurement of decay data with high precision, with the ultimate goal of confirming the existent nuclear values and/or lowering their uncertainties. Precise nuclear data is extremely important in the description of galactic events, in the nuclear dating of samples, as well in the evaluation of the toxicity of nuclear waste....

959. SHINE Phase II of IV: a focus on Lu-177

Cory Hawkins (SHINE Technologies)

17/05/2022, 10:50

Production and Application of Radionuclides

Verbal

As part of a long-term vision to deploy fusion technology in a scalable path to practical fusion energy, SHINE Technologies has ventured to produce lutetium-177. While a one-of-kind Mo-99 production plant is being constructed, SHINE’s Therapeutics division is currently manufacturing small quantities of 177LuCl3 to support clinical studies for cancer radioligand therapy. SHINE expects a...

983. Metal-organic frameworks as adsorbent for the 99Mo/99mTc generator

Chao Ma

17/05/2022, 11:10

Production and Application of Radionuclides

Verbal

This work explored the potential of several metal-organic frameworks (MOFs) as adsorbents for the development of 99Mo/99mTc generator using 99Mo produced by neutron capture of 98Mo which is hampered by its low specific activity. The molybdenum adsorption performance of MOFs, including adsorption kinetics and isotherms, were determined and adsorption mechanism was studied by several analytical...

994. Nuclear fission products from the SINQ gas-jet facility

Mr Georg Tiebel (ETH Zurich / Paul Scherrer Institute)

17/05/2022, 11:30

Production and Application of Radionuclides

Invited

Neutron-induced fission of ${}^{\text{235}}$U leads to a variety of radionuclides. With such targets being hosted in the inner shielding shell of the Swiss Spallation Neutron Source SINQ at the Paul Scherrer Institute, the produced radionuclides can be readily transported to the radiochemical laboratory by the SINQ gas-jet installation. The transport of the resulting fission products occurs...

907. Separation of 213Bi via an inverse 225Ac/213Bi radionuclide generator based on sulfonated carbon materials

Mr Hongshan Zhu (Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium)

19/05/2022, 15:30

Production and Application of Radionuclides

Invited

Bismuth-213 (213Bi) is an alpha-emitting radioisotope with large potential in nuclear medicine for cancer treatment. Several clinical trials of 213Bi-based radiopharmaceuticals have provided evidence for its therapeutic efficacy. 213Bi is produced from the relatively long-lived parent nuclide actinium-225 (225Ac) and then separated in a radionuclide generator. The patient dose of 213Bi is...

999. Preparation Thin Film Sources of Radiolanthanides for the Measurement of Auger Electron Energies and Branching Ratios

Noemi Cerboni (Paul Scherrer Institute (PSI))

19/05/2022, 16:00

Production and Application of Radionuclides

Verbal

With recent advances in the use of novel radiolanthanides for targeted Auger electron therapy, the request for precise and controlled dosimetry has increased in importance. So far, no experimental data for the energy and branching ratios of Auger electrons have been reported for Auger-electron-emitting lanthanides. One of the main challenges related to such measurements is the production of a...

1007. Molybdenum nanoparticles as target for the production of molbydenum-99

Pablo Serra Crespo (Joint Research Centre, European Commission)

19/05/2022, 16:20

Production and Application of Radionuclides

Verbal

The main objective is to develop a new production route for high specific activity molybdenum-99 based on the irradiation of molybdenum nanoparticles. In order to achieve this, molybdenum nanoparticles have been produced by spark ablation.
The spark ablation technology provides an easy method to produce nanoparticles with controlled size. It consists of a gas phase physical process in which...

895. Designing metal oxide-based stationary phases for the separation of Ac-225 and Bi-213 for biomedical applications

Ms Hilde Lenaerts (University of Antwerp, Department of Chemistry, Laboratory of Adsorption and Catalysis (LADCA), Universiteitsplein 1, 2610 Wilrijk, Belgium; Flemish Institute for Technological Research (VITO NV), Boeretang 200, 2400 Mol, Belgium; Belgian Nuclear Research Centre (SCK CEN), Institute for Materials Science, Boeretang 200, 2400 Mol, Belgium)

19/05/2022, 16:40

Production and Application of Radionuclides

Verbal

Cancer is a disease that still kills nearly 10 million people every year [1] despite the countless existing treatments. The amount of novel therapies is growing every day and targeted alpha therapy is one of them. Herein, the patient is treated with a radiopharmaceutical that binds to the cancer cell and emits ionizing radiation to induce cell damage. Since alpha radiation has a very short...

905. Measurements of cumulative cross sections

Sandor Takacs (Institute of Nuclear Research)

19/05/2022, 17:15

Production and Application of Radionuclides

Poster

By definition a cumulative production cross section of a radionuclide includes formation via direct nuclear reactions and formation via radioactive decay of the precursor nuclide (considering isomeric transition too). In literature different definitions of the cumulative cross sections exist.
The solution of the coupled differential equation describing the radioactive growth and decay for a...

1002. Production of high specific activity 51Cr by chromium-based metal-organic frameworks and the Szilard-Chalmers effect

Chao Ma

19/05/2022, 17:33

Production and Application of Radionuclides

Poster

Chromium-51 (51Cr) is an attractive radionuclide in the clinical application for labelling of red blood cells, diagnosis of gastrointestinal bleeding and assessing life span of red cells. This work reports that synthesis of two chromium based metal-organic frameworks (MOFs) as radiation targets to produce high specific activity 51Cr production utilizing the Szilard-Chalmers effect. First, the...

1079. Production of 212Pb tracer from 232Th and its application to investigate lead chemistry in acidic nitro-phosphate solutions

Deniz Avsar

19/05/2022, 17:51

Production and Application of Radionuclides

Poster

Abstract

Lead occurs in small amounts in the nature mainly as lead sulfide, however the main exposure and contamination are largely results of increased anthropogenic use (e.g. mining, refining, lead-acid batteries, paints, gasoline). Lead is a cumulative toxicant, and extensive use causes environmental contamination and health problems. The recommended limit for lead in drinking water is...

1119. Designing metal oxide-based stationary phases for the separation of Ac-225 and Bi-213 for biomedical applications

Hilde Lenaerts

19/05/2022, 18:10

Poster

882. IRRADIATION OF YTTRIUM MICROSPHERES AT THE IRT-T REACTOR

Vladimir Sadkin (National Research Tomsk Polytechnic University)

Production and Application of Radionuclides

Poster

National Research Tomsk Polytechnic University (TPU), together with an industrial partner (BEBIG), start produced yttrium microspheres at its research nuclear reactor this fall. This radiopharmaceutical is intended for the treatment of liver cancer in inoperable patients and, unlike analogs, it destroys the tumor in a targeted manner without affecting healthy organs and tissues.
Irradiation...

885. Production of thorium-227 experimental samples: problem of actinium-227 impurity control

Mr Pavel Butkaliuk (JSC “SSC RIAR”)

Production and Application of Radionuclides

Poster

Thorium-227 radionuclide is perspective as a part of radiochemicals for therapy of various types of cancer. It forms strong complexes with monoclonal antibodies due to its chemical properties. In case of its full decay, five alpha particles are emitted, though there are some concerns related to the opportunity of its daughter radionuclide radium-223 uncontrolled migration over the patients’...