Speaker
Description
Extracellular vesicles (EVs) are membrane-bound structures released by the cells in the extracellular compartment. EVs are very heterogeneous in size and their internal cargo. The major role of EVs is intercellular communication, which is achieved by molecular mediators (nucleic acids, proteins, lipids and small molecular weight metabolites) carried by EVs, thus able to modify the function and/or fate of recipient cells.
Bone marrow is a particularly radiosensitive organ, where radiation damage of the stem cell compartment can be significantly modulated by signals received from the microenvironment. Thus, intercellular signalling is a key mechanism in modulating radiation damage in the bone marrow. A growing number of evidence shows that EVs play an important role in the manifestation of ionizing radiation-induced acute and late bone marrow damage. This presentation aims to give an overview on how EVs by transmitting radiation-induced signals to non-targeted cells within the hematopoietic system are able to modulate the level of radiation damage.
This project has received funding from the Horizon-EURATOM under grant agreement 101061037 (PIANOFORTE).
| Preferovaná sekcia | Biologické účinky žiarenia a odhad rizika z ožiarenia |
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