In the present study, the carboxymethyl cellulose (CMC) hydrogel containing activated carbon-silver nanoparticles (Ag NPs) composites (Acc-Ag composites) was fabricated for the highly functional wound-dressings by electron beam irradiation. For this, the Acc-Ag composites were first prepared using a thermal treatment under an inert argon (Ar) atmosphere. During the thermal treatment, the Ag ions were successfully changed to metallic Ag NPs, and NO3 anion with a potential cytotoxicity was simultaneously eliminated. Thereafter, the Acc-Ag composites were mixed with an aqueous CMC solution, and then the hydrogel was prepared by electron beam irradiation. The optimum manufacturing condition of the CMC hydrogel containing the Acc-Ag composites was examined with a variation of composite/hydrogel ratio and irradiation dose. The various physical/chemical properties of CMC composite hydrogel were characterized. The resulting CMC composite hydrogel was examined via wound regeneration test. Therefore, the CMC hydrogel containing the Acc-Ag composites was found to have a great potential for functional wound dressings.