13-18 May 2018
Casino Conference Centre
Europe/Prague timezone

Solid phase extraction based Lu-177m/Lu-177 radionuclide generator to produce Lutetium-177

14 May 2018, 17:15
1h 30m
Gallery (Casino Conference Centre)

Gallery

Casino Conference Centre

Poster Separation Methods, Speciation Poster SEP

Speaker

Mrs Rupali Bhardwaj (TU Delft)

Description

The radionuclide lutetium-177 has become one of the preferred radionuclides for targeted therapy. The low tissue penetration of the emitted β- particles assures an efficient energy deposition on small size tumours (less than 3 mm) and a low radiation dose to the surrounding healthy tissue. This is especially useful when 177Lu is combined with different targeting molecules, which are internalized within tumour cells, being then possible to treat small primary and metastatic tumours, like prostate, breast, melanoma, lung and pancreatic tumours as well as bone metastasis. Recently we have proposed a 177mLu/177Lu radionuclide generator as a new method for the production of lutetium-177 [1]. The reported separation method, increases the 177Lu/177mLu activity ratios from 0.25 (in equilibrium) to values around 250 [2]. In our current research we are exploiting the convenience of solid-liquid phase extraction for the separation of the two isomers.
In order to achieve this separation, the surface of amino propyl silica has been chemically modified by reacting it with different chelating groups like : 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and its analogous namely, 2,2′,2”-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid (DOTAGA-anhydride) and Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA-tris(tert-butyl ester)). The modified silica surfaces are characterized with several techniques including infrared spectroscopy, solid-state 13C-NMR and TGA analysis. The chelator bearing particles are then packed in a column and loaded with 177mLu. Periodically the produced 177Lu is eluted an its quality and the efficiency of the process are quantified by gamma spectroscopy.
This system offers advantages like easy of operation and reliability that together with the low kinetics of the chelating moieties make the system a great candidate to be the final design of the 177mLu/177Lu generator.

  1. De Vries, D.J. and H. Wolterbeek, The production of medicinal 177Lu and the story of 177mLu: detrimental by-product or future friend? Tijdschr. Nucl. Geneeskd, 2012. 34: p. 899-904.
  2. Bhardwaj, R., et al., Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects. Scientific Reports, 2017. 7: p. 44242.

Primary author

Mrs Rupali Bhardwaj (TU Delft)

Co-authors

Prof. Bert Wolterbeek (Radiation Science and Technology, Delft University of Technology, Delft, the Netherlands) Dr Antonia Denkova (Radiation Science and Technology, Delft University of Technology, Delft, the Netherlands) Pablo Serra Crespo (TU Delft)

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