RadChem 2014

Preparationof Ra-223 by neutron irradiation of Ra-226

May 15, 2014, 5:30 PM

1h 15m

Gallery (Casino Conference Centre)

Poster Production and Application of Radionuclides Poster Session - Production and Application of Radionuclides

Speaker

Ekaterina Kukleva (Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering)

Description

Radium-223 is prospective alpha-emmiting therapeutic radionuclide for targeted radionuclide therapy. Although Ra-223 is formed naturally by the decay of U-235, for practical reasons its preparation involves neutron irradiation of Ra-226. The decay of Ra-227 leads to Ac-227, which decays to Th-227 and Ra-223 subsequently. Ra-226 as a decay product of U-238 is generally available in multigram quantities (mainly historical stock). Main purpose of this study was to experimentally and theoretically evaluate and verify available literature data on productionof Ra-223. According to dates obtained from gamma spectra, the yield of this irradiation and cross sections were calculated. Radium-226 sample was flame-sealed in a quartz ampoule and irradiated for 11,7 days in a neutron flow. The yield of Ra-223 and other products were determined several weeks after EOB by evaluation of gamma and alfa spectra. Less than one month after irradiation Ra-223, Pb-212, Bi-212, Tl-208 peaks can be found on gamma spectra. In three – four month the best peaks can be seen are peaks of Pb-214 and Bi-214, which are decay products of Ra-226. Also peaks of Ac-227, Th-227, Ra-223, Pb-211, Th-228 and Ra-224 can be found, but some of them are interfered by Pb-214 and Bi-214 peaks, other of them are very small in compare with Pb-214 and Bi-214. Partially supported by grants LK21310 and TA03010027.

Presentation materials

Paper

manuscript_223Ra.pdf