May 11 – 16, 2014
Casino Conference Centre
Europe/Prague timezone

Effect of mobile phase salinity on the Ac-227/Ra-223 generator.

May 12, 2014, 5:15 PM
1h 30m
Gallery (Casino Conference Centre)


Casino Conference Centre

Reitenbergerova 4/95, Mari&#225;nsk&#233; L&#225;zn&#283;, Czech Republic <font color=white>
Poster Separation Methods, Speciation Poster Session - Separation Methods, Speciation


Dr Jan Kozempel (FJFI CVUT)Ms Lucie Kománková (FJFI CVUT)


Radium-223 is the first approved alpha emitting radionuclide for use in radionuclide therapy [1]. Radium follows the Calcium metabolism and thus is self targeted to bones. Several generator systems were described in the past [2]. In this study we have focused on a generator system described by Guseva et al. [3], based on a Dowex-1 resin and a mixed methanol/ nitric acid mobile phase. The effect of NaCl addition into a mobile phase on Ac-227/Th-227/Ra-223 generator was studied. The aim of this study was to increase the efficiency of Ra-223 elution and improvement of the Ra-223 elution peak shape. Possible Th-227 breakthrough was also evaluated. Acknowledgement This work was supported by the Ministry of Education Youth and Sports of the Czech republic, grant No.: LK21310. References 1. Xofigo®, European pharmacopoeia Reg. No.: EU/1/13/873/001 2. McAlister, D. R., Horwitz, E.P.: Chromatographic generator systems for the actinides and natural decay series elements. Radiochimica Acta 99, 151–159 (2011). 3. Guseva, L. I., Tikhomirova, G. S. and Dogadkin N. N.: Anion-Exchange Separation of Radium from Alkaline-Earth Metals and Actinides in Aqueous-Methanol Solutions of HNO3. 227Ac - 223Ra Generator. Radiochemistry 46, 1, 58-62 (2004).

Primary authors

Prof. Ferdinand Šebesta (FJFI CVUT) Dr Jan Kozempel (FJFI CVUT) Ms Lucie Kománková (FJFI CVUT)


Ms Ekaterina Kukleva (FJFI CVUT) Mr Martin Vlk (FJFI CVUT) Ms Petra Mičolová (FJFI CVUT)

Presentation materials