Speakers
Dr
Jan Kozempel
(FJFI CVUT)Ms
Lucie Kománková
(FJFI CVUT)
Description
Radium-223 is the first approved alpha emitting radionuclide for use in radionuclide therapy [1]. Radium follows the Calcium metabolism and thus is self targeted to bones. Several generator systems were described in the past [2]. In this study we have focused on a generator system described by Guseva et al. [3], based on a Dowex-1 resin and a mixed methanol/ nitric acid mobile phase. The effect of NaCl addition into a mobile phase on Ac-227/Th-227/Ra-223 generator was studied. The aim of this study was to increase the efficiency of Ra-223 elution and improvement of the Ra-223 elution peak shape. Possible Th-227 breakthrough was also evaluated.
Acknowledgement
This work was supported by the Ministry of Education Youth and Sports of the Czech republic, grant No.: LK21310.
References
1. Xofigo®, European pharmacopoeia Reg. No.: EU/1/13/873/001
2. McAlister, D. R., Horwitz, E.P.: Chromatographic generator systems for the actinides and natural decay series elements. Radiochimica Acta 99, 151–159 (2011).
3. Guseva, L. I., Tikhomirova, G. S. and Dogadkin N. N.: Anion-Exchange Separation of Radium from Alkaline-Earth Metals and Actinides in Aqueous-Methanol Solutions of HNO3. 227Ac - 223Ra Generator. Radiochemistry 46, 1, 58-62 (2004).
