RadChem 2014

Session

Radiopharmaceutical Chemistry, Labelled Compounds 2

RPH-2

15 May 2014, 08:30

Casino Conference Centre

Conveners

Radiopharmaceutical Chemistry, Labelled Compounds 2

• Emma Aneheim (Sahlgrenska Academy at Gothenburg University)
• Kattesh Katti (University of Missouri)

371. Radioactive Gold Nanoparticles In Nanomedicine: Neutron Activation and Radiochemical Approaches In Green Nanotechnology

Prof. Kattesh Katti (University of Missouri)

15/05/2014, 08:30

Radiopharmaceutical Chemistry, Labelled Compounds

Invited

Effective delivery of radiopharmaceuticals, chemotherapeutic, hormonal and biological pharmaceuticals to the tumor tissue and cancer cells selectively continue to be the most vexing problems in cancer oncology. Radioactive nanoparticles with diagnostic and therapeutic capabilities provide intelligent drug delivery systems to maximize therapeutic activity and to minimize undesirable...

331. An asymmetric approach to the synthesis of a carbon-11 labelled gliotransmitter D-serine

Dr Alexander Popkov (Department of cognitive research and tomographic imaging methods, Samo University)

15/05/2014, 09:00

Radiopharmaceutical Chemistry, Labelled Compounds

Verbal

Endogenous D-serine is a co-transmitter of glutamate for synaptic N-methyl-D-aspartate receptors (NMDARs). Receptor affinity for binding D-serine versus glycine depends on its GluN2 subunit composition. For the activation of NMDARs glutamate binds to the GluN2 subunit of the receptor and a second ligand binds to the GluN1 subunit. D-serine is an endogenous ligand for the glycine site of the...

321. 18F]Flumazenil, Radioligand of the Central Benzodiazepine Receptors: A Systematic Study of Synthesis and Purification Parameters

Dr Natalia Gomzina (N.P.Bechtereva Institute of the Human Brain, Russian Academy of Sciences (IHB RAS), St. Petersburg, Russia)

15/05/2014, 09:20

Radiopharmaceutical Chemistry, Labelled Compounds

Verbal

Positron emission tomography (PET) is an imaging modality that allows in-vivo studies of physiological and biochemical processes on molecular level. Radiolabeled flumazenil analogues are important radiopharmaceuticals for the assessment of the central benzodiazepine receptors (cBZR) density by PET. These receptors play an important role in many neurological and psychiatric disorders, such as...

438. Prospective carriers of 223-Ra for targeted alpha particle therapy.

Dr Jan Kozempel (FJFI CVUT)

15/05/2014, 09:40

Radiopharmaceutical Chemistry, Labelled Compounds

Verbal

Targeted alpha particle therapy (TAT) is very powerfull tool against cancer, since DNA double-strand breaks caused by alpha radiation induce cells death. Main advantage of radionuclides decaying by alpha particle cascade in a short-lived chain is the deposition of high energy in very small volume (approx. 27 MeV in the case of 223-Ra). However main disadvantage of such in vivo generator is...