11–16 May 2014
Casino Conference Centre
Europe/Prague timezone

Ga-68 Citrate as Promising Agent for PET

15 May 2014, 17:30
1h 15m
Casino Conference Centre

Casino Conference Centre

Reitenbergerova 4/95, Mari&#225;nsk&#233; L&#225;zn&#283;, Czech Republic <font color=white>
Poster Radiopharmaceutical Chemistry, Labelled Compounds Poster Session - Radiopharmaceutical Chemistry, Labelled Compounds

Speaker

Ms Tatyana KHAUSTOVA (Burnasyan FMBC)

Description

Ga-67 citrate has large clinical application in imaging of infection and inflammation focal sites using SPECT. For today there is a possibility of creation of its PET-analogue due to commercial availability of Ga-68 generator. As a consequence, the researches of various scientific and medical centers all around the world were aimed at assessing the suitability of diagnostic Ga-68 citrate for PET imaging of infection and inflammation focal sites. First of all, the composition of lyophilized product was optimized. The content of sodium citrate should correspond to the concentration of 0.08±0.01 M in the final solution of the product (Ga-68 citrate). RPh was prepared by introducing of concentrated and purified eluate (2 mL) of Ge-68/Ga-68 generator (Ga-68 chloride complex solution in 0.1 M HCl) into the vial with lyophilized composition. Then the vial was incubated at room temperature for 10 min. Another way of RPh preparation was mixing the eluate of Ge-68/Ga-68 generator with an aqueous solution of sodium citrate (the citrate concentration in the final solution was 0.08 M). The radiochemical purity of these RPhs was determined by thin layer chromatography using cellulose (Merck 5574) and silica gel (Merck 5553) on aluminum plate and the mixture of acetonitrile-water (1:1) as a the mobile phase. The value of the radiochemical purity was not less than 90% in both cases. Experiments to study the biodistribution of Ga-68 citrate were also carried out. The results showed that the use of transferrin receptor blockade achieves much more acceptable biodistribution results. Studies on pharmaceutical development of this RPh will be continued.

Primary author

Ms Tatyana KHAUSTOVA (Burnasyan FMBC)

Co-authors

Dr Alexander Bruskin (Burnasyan FMBC) Anton Larenkov (Burnasyan FMBC) Ekaterina Lesik (Burnasyan FMBC) Prof. Galina Kodina (Burnasyan FMBC) Maria Zhukova (Burnasyan FMBC)

Presentation materials

There are no materials yet.