Ms
Petra Mičolová
(Department of Nuclear Chemistry, Faculty of Nuclear Science and Physical Engineering, Czech Technical University, Brehova 7, 115 19 Prague 1, Czech Republic)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Triterpenes are natural substances obtained by isolation from common species of plants and fruits. Together with its semisynthetic derivatives, have different biological effects such as analgesic, antibacterial, antiosteoporotic, antihypertensive, antimicrobial, diuretic, antiviral, hepatoprotective, anti-inflammatory or a wide range of antitumor activities.
From this perspective are...
Ms
Vanessa Sanders
(University of Nevada Las Vegas)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Radiopharmaceuticals are very powerful diagnostic tools for evaluation of a host of medical conditions. These drugs are labeled with radioactive isotopes which are utilized to create pictures of areas of interest through absorption of the drug. They are currently in high demand due to their ability to image areas that traditional imaging devices cannot. The main differences between...
Dr
Seweryn Krajewski
(Institute of Nuclear Chemistry and Technology, Warsaw, Poland)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Objectives: In clinical practice, there is a demand for no-carrier-added radionuclides emitting particles of short range that demonstrate a therapeutic effect on small neoplastic lesions diffuse over a large area of tissue or tumour metastases. Rhodium-105 meets all requirements for application in radionuclide therapy [1] and might be an alternative to 177Lu. Tetrathioether crown complexes...
Mr
Aleksandr Zverev
(Vasilievich)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Chromatographic separation of In-111 from irradiated cadmium
by using ampholyte Chelex–100 and carbon sorbent
A. V. Zverev1, O. I. Andreev1, G. E. Kodina2
1Federal Center of Nuclear Medicine Projects Design and Development, Moscow, Russia; 2Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Early diagnosis of malignant tumors remains one of the urgent problems of the modern...
Ms
Bayirta Egorova
(Lomonosov Moscow state university)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
The complexation of alpha- beta- and Auger- emitting radionuclides is under investigation for the target delivery of them to tumor cells. The search of new effective binding chelating molecules with fast kinetics of complex formation should be carried out among H4DOTA analogs as it is currently used for radiopharmaceuticals. Water soluble new azamacrocyclic compounds show not only...
Ms
Tatyana KHAUSTOVA
(Burnasyan FMBC)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Ga-67 citrate has large clinical application in imaging of infection and inflammation focal sites using SPECT. For today there is a possibility of creation of its PET-analogue due to commercial availability of Ga-68 generator.
As a consequence, the researches of various scientific and medical centers all around the world were aimed at assessing the suitability of diagnostic Ga-68 citrate for...
Dr
Olga Mokhodoeva
(Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
The short range of α-particles (<100 μm) and high linear energy transfer (LET) in tissue make α-particle emitting radionuclides an ideal tool for targeted radiotherapy of cancer. A number of preclinical and clinical studies have shown the advantages of 223Ra for treatment of bone tumor and skeletal metastases due to its chemical similarity to calcium [1]. Therefore, Ra injected intravenously...
Mr
Martin Vlk
(Department of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, CTU Prague)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Natural triterpenoids together with their semisynthetic derivatives form basis for extensive medicinal research, because they have shown various biological activities [1], e.g.: antineoplastic, antiviral, anti-inflammatory, antimicrobial activities, hepato- and cardioprotective effects; and reveal a great potential for pharmaceutical applications when their cytotoxic and anti-HIV activities...
Dr
Nadezhda Shchepina
(Head of the laboratory of Radiochemistry)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Nuclear-chemical method, based on tritium β-decay in hydrocarbons, gives chemists unique opportunity of carbocations generation. Nucleogenic phenyl cations (cations generated by β-decay) and their further ion-molecular reactions with different nucleophiles have been used previously by us for the preparation of unknown and hardly available biologically active monoazine derivatives [1-5]....
Ekaterina Kukleva
(Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Main aim of this study was the revision of the synthetic methods of cisplatin, or cis-diamminedichloroplatinum(II) with an outlook to the preparation of 195mPt-labelled complex. [1]
Historically it was the first member of platinum-containing cytostatic drug. Nowadays carboplatin and oxaliplatin are also being used as the non-specific anticancer drugs. Cisplatin reacts with nitrogen in purine...
Mr
Martin Vlk
(Department of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, CTU Prague)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
Series of indole-3-acetic acid derivatives substituted in the benzene ring belongs to the natural plant growth hormone – auxines, with interesting biological activities (e.g. specific antigen stimulation in atopic allergic disease by interleukin 4 and 5). They have recently been made via Fisher ring closure of the succin-aldehydic acid phenylhydrazones obtained from glutamic acid or direct...
Dr
Przemysław Koźmiński
(Institute of Nuclear Chemistry and Technology)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
There are around 36 million people in the world with Alzheimer’s disease and up to now here is no cure for this ailment. Alzheimer’s disease is the most common form of dementia. One of the drugs used for the treatment of Alzheimer's disease is tacrine - the inhibitor of cholinesterase. The aim of this work was to label with technetium-99m the different analogue of tacrine (containing different...
Ms
Tatyana Khaustova
(Burnasyan FMBC)
5/15/14, 5:30 PM
Radiopharmaceutical Chemistry, Labelled Compounds
Poster
At present a large attention is given to the synthesis and study of new organic compounds as the potential components of bone imaging agents. Phosphonates are promising class of organic compounds for these purposes. Their 99mTc-based derivates are used for bone imaging with the Single Photon Emission Computed Tomography (SPECT) [1]. Imaging with 68Ga-labeled radiopharmaceuticals have gained...
