Speaker
Prof.
Mohammad Anwar Chaudhri
(Inst. of Biophysics,Center of Medical Physics & Technology, Uni. of Erlangen-Nuernberg, Gedrmany)
Description
The generator system Ac-225 / Bi-213 (half life of 45.6 min) is a suitable method of producing an alpha-emitter for targeted alpha thertapy ). However, the production of Ac-225 is difficult and only a limited quantity of this isotope has so far been available for clinical use. Till recently it was exclusively produced by the decay of Th-229, which itself is generated by the decay of U-233 (half life of 159200 years). By making use of our production yield curves we have estimated the production of Ac-225 through (p,2n) and (d, 3n) on Ra-226, and also estimated the unwanted activities being produced simultaneously through (p,n), (d,n) and (d,2n) reactions on Ra-226. It is shown that from a thick Ra - target production yields of 1.1 x 10 10 Bq, 1.85 x 10 10 Bq and 2.04 x 10 10 Bq respectively at proton bombarding energies of 20, 30 and 34 MeV can be obtained at incident proton currents of 100 µA but irradiation time of only one day which is a lot more practical than previously quoted 10 days of irradiation. Similarly production yields of Ac-225 through the (d,3n) reactions on Ra-226 have also been estimated to be 4.2 x 10 9 Bq, 1.1 x 10 10 Bq and 1.4 x 10 10 Bq at deuteron energies of 20, 30 and 34 MeV respectively for irradiation time of 1 day at beam intensities of 100 micro-A. As the production yields data is presented in graphical form, the production of Ac-225, from a moderately thick or even a thin Ra-226 target can also be obtained for any irradiation conditions.
Primary author
Prof.
Mohammad Anwar Chaudhri
(Inst. of Biophysics,Center of Medical Physics & Technology, Uni. of Erlangen-Nuernberg, Gedrmany)
Co-author
Mr
M. Nasir Chaudhri
(Pakistan Council of Scientific & Industrial Research, Lahore)
