Background and Aims:
Vascular adhesion protein-1 (VAP-1) is an endothelial glycoprotein present on the endothelial surface of tissues affected by infection/inflammation that recruit lymphocytes from blood. VAP-P1 is a VAP-1 selective peptide (sequence GGGGKGGGG) which, according to previous studies, conjugated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and...
195mPt is isomeric radionuclide with the great prospect for use in nuclear medicine, due to high yield of Auger electrons, good for small malignancies treatment, mild gamma-radiation for medication distribution control without almost any damage to healthy tissues. These properties perfectly suit personalized approach for treatment of cancer which is developed into theranostics in...
The application of 68Ga –labeled peptide for tumor diagnosis is growing very fast in the recent years. One of the traced peptide for tumor diagnosis in nuclear medicine is [68Ga]GaDOTA-TOC. The aim of the work was GMP preparation of [68Ga]GaDOTA-TOC for application in nuclear medicine for a routine diagnosis using automated production with TRACERlab® MX module and quality control according to...
Over the past several decades nuclear medicine turned into an integral part of clinical practice in developed countries. The therapeutic radiopharmaceuticals (RPh), developed and currently used in Russia, are applied for treatment of oncological diseases, but due to their versatility, RPh can be useful in other fields of medicine.
For this purpose formulation development of a medication on...
Hydroxyapatite based materials including nanoparticles (HAp-NPs) are widely used in medicine because of their stability in various biological media [1]. The HAp-NPs also belong to promising drug carrier systems for medicinal radionuclides such as F-18 as the part of multipurpose theranostic system with other therapeutic and diagnostic radionuclides [2]. HAp-NPs can show uptake by cancer tissue...
Superparamagnetic iron oxide nanoparticles (SPIONs) are being studied as contrast agents and drug delivery vehicles in medicine, mainly for easy preparation, low toxicity, biocompatibility and their magnetic properties. SPIONs have become a promising tool in the magnetic resonance imaging, magnetic drug targeting, hyperthermia anti-cancer strategy, and enzyme immobilization. The scope of our...
The present development is aimed at creation of thermo-collapsing radiopharmaceuticals for brachytherapy based on thermo-sensitive copolymers with chelated beta-emitting radionuclide 153Sm. The preparation is a polymer solution and is made of two components, each loads individual function.
The task set in this development is solved with component-wise division of the radiopharmaceutical’s key...
Different methods are available for the purification of recovered enriched water from FDG synthesis units. Procedures for organic solvents elimination as: irradiation of the water with UV light, oxidation with KMnO4/NaOH (Rötering et al., 2015), electrolysis (Huang et al., 2003; Weber et al., 2003), ozonolysis (Asti et al., 2007) or He gas purging are proposed. All these methods can remove...
Hydroxyapatite (HAp) is one the main mineral bones and teeth components and biocompatible material used in orthopaedic implants. It might be used as a drug carrier in diagnostics and treatment of cancer. The sufficient in vivo stability without fast aggregation of the Hap-NPs is required for theranostic application. Various phosphonic acids were studied as potential HAp stabilisers and...
Pertechnetate (TcO4-–) is among the anions that are considered the most environmentally mobile. This is due to its relatively large size and low negative charge density distributed at the four oxygen atoms [1-4]. The negatively charged anions repel from the negatively charged surface of most minerals. Conversely, they are attracted by positively charged residues of nitrogenous bases like...
