RadChem 2010

Session

Nuclear Methods in Medicine, Radiopharmaceuticals and Diagnostics, Labelled Compounds 1

RF1

Apr 22, 2010, 8:00 AM

Casino Conference Centre

24. New amino acid synthons for preparation of [¹⁸F]FDOPA and α-[¹¹C]methyl amino acids for positron emission tomography

Dr Alexander Popkov (Department of Information Systems, Faculty of Health and Social Studies, University of South Bohemia)

4/22/10, 8:00 AM

Nuclear Methods in Medicine, Radiopharmaceuticals and Radiodiagnostics, Labelled Compounds

Verbal

PET diagnostics using radiolabelled amino acids is an emerging branch of nuclear medicine. This includes visualisation and grading of brain, neuroendocrine and prostata tumours, measurement of protein synthesis rate in tumour cells, quantitative in vivo measurement of dopamine and serotonin metabolism in brain. Development of clinical applications is limited by complexicity of robotic devices...

140. Optimisation of the radiosynthesis of 4-[¹⁸F]fluoromethyl-L-phenylalanine and [¹⁸F]FET via a same Scintomics automated synthesis hotboxthree module.

Mr Ken Kersemans (Vrije universiteit Brussel)

4/22/10, 8:30 AM

Nuclear Methods in Medicine, Radiopharmaceuticals and Radiodiagnostics, Labelled Compounds

Verbal

It was recently reported that the success of O-(2’-[18F]fluoroethyl)-L-tyrosine ([18F]FET) as PET tracer is limited to brain, head and neck tumours and that there is still a need for more potent amino acid analogues for peripheral tumour imaging. We hereby report on the radiosynthesis of a new tracer 2-Amino-3-(4-[18F]fluoromethyl-phenyl)-propionic acid (4-[18F]FMP), taken up in tumours by the...

186. Heterocyclic labelled derivatives of Betulinines

Mr Martin Vlk (Department of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, CTU Prague)

4/22/10, 8:45 AM

Nuclear Methods in Medicine, Radiopharmaceuticals and Radiodiagnostics, Labelled Compounds

Verbal

The lupane type compounds have played a singular role among pentacyclic cytotoxic triterpenoids from the beginning of 21^st century, mainly for their various biological activities¹, which include antineoplastic, antiviral, anti-inflammatory, antimicrobial activities and also hepato- and cardioprotective effects. The derivatives of betulin and betulinic acid have been...

10. Preparation of [⁴⁸V]TiO₂ labelled nanoparticles for biokinetics studies.

Mr Ján Kozempel (European Commission, IHCP - JRC, Ispra)

4/22/10, 9:00 AM

Nuclear Methods in Medicine, Radiopharmaceuticals and Radiodiagnostics, Labelled Compounds

Verbal

Engineered nanoparticles are of current interest in many applications (e.g. industry, medicine, energy). As they are produced in ever higher quantities, the need to assess their biokinetics and toxicity becomes more and more important. The aim of this study was to prepare stable, radiolabelled bioavailable TiO₂ nanoparticles to assess their in vivo biokinetics. The preparation of...