Speaker
Description
Accurate assessment of committed effective dose following occupational intake of radionuclides requires updated biokinetic models, robust statistical inference, and comprehensive uncertainty management. Although the ICRP Occupational Intakes of Radionuclides (OIR) series provides state-of-the-art systemic models, retention and excretion functions, and dose coefficients, their operational implementation in transparent assessment tools remains limited.
CADORmed III was developed by EDF and EURADOS Working Group 7 to address this need. It is a freely accessible, non-commercial Excel®-based application for the assessment of acute occupational intakes. The software implements the latest ICRP OIR models (Publications 130, 134, 137, 141 and 151) and follows EURADOS/IDEAS Technical Recommendations, European Commission Radiation Protection 188 guidance, and ISO 27048:2011.
Intake estimation is performed using maximum likelihood methods. Goodness of fit is evaluated through chi-squared statistics incorporating both Type A (random) and Type B (systematic) uncertainties via scattering factors, consistent with EURADOS methodology. The workflow includes import of dose coefficients and retention/excretion functions from the ICRP OIR Data Viewer, flexible selection of radionuclide-specific parameters (intake route, absorption type, AMAD), and graphical comparison of measured and predicted activity data. Both in vivo and in vitro measurements are supported, including results below detection limits using predefined substitution approaches with adjusted uncertainties.
Advanced features enable the modeling of mixed intake routes, combined absorption types, and uncertain intake dates, with the option for the user to manually select and enter the intake date. The tool is further illustrated through a real case of occupational internal contamination due to Co-60 incorporation, demonstrating applicability under realistic monitoring conditions.
Formal validation within EURADOS WG7, including participation in the ICIDOSE-2 intercomparison, demonstrated that the obtained results fall well within the established acceptability criteria, confirming statistical robustness and reliability. CADORmed III provides a validated and transparent implementation of the ICRP OIR framework supporting harmonized and reproducible internal dose assessment.