ICDA-5

Session

Micro- and nanodosimetry

Jun 8, 2026, 11:00 AM

CTU in Prague, Faculty of Nuclear Sciences and Physical Engineering (Prague, Czechia)

55. AtoMiQA: A Tool for Microdosimetric Quality Assurance

Anna Bianchi (INFN Laboratori Nazionali di Legnaro (LNL))

6/8/26, 11:00 AM

Micro- and nanodosimetry

Oral Presentation

In hadron therapy, accurate measurement of radiation quality remains a critical unmet need. While treatment planning systems (TPS) increasingly implement variable relative biological effectiveness (RBE) models for protons, for carbon ions, even if a variable RBE is applied, the clinical QA focuses almost exclusively on physical dose. Radiation quality, which strongly drives RBE and...

58. Three-Dimensional Analysis of Nano- and Microscale Dose Distributions in Nanoparticle-Enhanced Radiotherapy: Impact of Energy Deposition Heterogeneities on Dose Enhancement Metrics

Evan Poket (HE2B ISIB (Institut Supérieur Industriel de Bruxelles) - Belgium)

6/8/26, 11:15 AM

Micro- and nanodosimetry

Oral Presentation

Nanoparticle enhanced radiotherapy under X-ray irradiation has been widely investigated as a promising strategy to locally modify energy deposition at the micrometric and nanometric scales. This method aims to optimize the patient’s cancer treatment by promoting the production of secondary particles in the vicinity of the nanoparticles and increasing local energy deposition while preserving...

79. Microdosimetric Interpretation of the Relative Efficiency of TLD-400 Under Photon, Electron and Proton Irradiation

Jyun-Wei Jheng (Department of Medical Imaging and Radiological Sciences, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City, 333323, Taiwan)

6/8/26, 11:30 AM

Micro- and nanodosimetry

Oral Presentation

The Thermoluminescence Dosimeter TLD-400 (CaF₂:Mn) exhibits high sensitivity to ionizing radiation and is widely used in radiotherapy and space dosimetry. A key characteristic of TLD-400 is its beam quality–dependent relative efficiency (η(λ,γ)), where thermoluminescence output varies among radiation types even at identical absorbed doses.

In this work, relative efficiencies were measured...

197. New microdosimeters for clinical BNCT

Anna Selva (INFN Laboratori Nazionali di Legnaro)

6/8/26, 11:45 AM

Micro- and nanodosimetry

Oral Presentation

Boron Neutron Capture Therapy (BNCT) is a hadron therapy strategy based on low-energy neutron irradiation of a tumor previously loaded with boron-10 atoms. The resulting radiation field is composed of several particles with varying biological effectiveness. Microdosimetry is a valuable tool to monitor this complex field, allowing to distinguish different dose components and providing a...

109. Experimental and Monte Carlo characterization of linear energy transfer and lineal energy in proton therapy beams

Maria Luz Olaguibe (Department of Oncology, Laboratory of Experimental Radiotherapy, Leuven, Belgium. Belgian Nuclear Research Center (SCK CEN), Mol, Belgium)

6/8/26, 12:00 PM

Micro- and nanodosimetry

Oral Presentation

Background
Dose-weighted linear energy transfer (LETd) is widely used in relative biological effectiveness (RBE) modeling; however, as an averaged quantity, it does not fully describe microscopic energy deposition patterns responsible for biological damage. Microdosimetry overcomes this limitation by describing energy deposition through probability distributions, with dose-weighted lineal...

129. Silicon Telescopes and Avalanche-Confinement TEPCs for Microdosimetry in Proton Therapy

Davide Bortot (Politecnico di Milano)

6/9/26, 11:00 AM

Micro- and nanodosimetry

Oral Presentation

Proton therapy treatment planning traditionally assumes a constant Relative Biological Effectiveness (RBE) of 1.1. However, growing evidence shows that proton RBE varies with depth, generally increasing toward the distal region of the Spread-Out Bragg Peak (SOBP). This variation is linked to changes in microscopic energy deposition as protons slow down in tissue, potentially leading to...

130. Silicon Microdosimetry for RBE Evaluation in Carbon-Ion Therapy: In-Field and Out-of-Field Measurements at CNAO

Davide Mazzucconi (Politecnico di Milano)

6/9/26, 11:15 AM

Micro- and nanodosimetry

Oral Presentation

Radiation therapy with carbon ions is characterized by high biological effectiveness due to the high Linear Energy Transfer (LET) of both primary ions and the secondary fragments produced along the beam path. In clinical practice, RBE calculations are typically based on radiobiological models which links microscopic energy deposition patterns to cellular response. Microdosimetry provides...

174. Nanodosimetry, track structure-based simulations, and radiation-induced biological effects

Dr Pavel Kundrát (Department of Radiation Dosimetry, Nuclear Physics Institute, Czech Academy of Sciences)

6/9/26, 11:30 AM

Micro- and nanodosimetry

Oral Presentation

Nanodosimetry focuses on measuring and simulating ionizations in low-pressure gas detectors that mimic tiny volumes and may serve as proxies for cellular DNA constituents and induction of clustered DNA damage. Nanodosimetry provides unprecedented measurements of physical parameters that govern biological effects of ionizing radiation. However, radiation-induced effects leading to biological...

177. Beyond Averages: Linking Track Structures, Microdosimetry, and Spatial Features of Radiation Induced DNA Damage

Chia-Wei Huang (Department of Dosimetry and Application of Ionization Radiation, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague; Department of Radiation Dosimetry, Nuclear Physics Institute, Czech Academy of Sciences)

6/9/26, 11:45 AM

Micro- and nanodosimetry

Oral Presentation

Biological effects of ionizing radiation arise from a sequence of stochastic processes, including particle interactions, radical chemistry, DNA damage induction, cellular repair, and tissue-level responses. Monte Carlo track structure simulations capture many of these early physical and chemical stages and enable mechanistic investigation of radiation quality effects. Despite this inherent...